The Burguete Lab investigates the mechanisms by which microsatellite repeat expansion causative of many disorders including ALS/FTD (C9orf72), the Spinocerebellar Ataxias and Huntington’s disease, and the Myotonic Muscular Dystrophies contribute to neurodegeneration. Our lab works with the novel hypothesis that highly structured microsatellite repeat RNAs could function as RNA localization signals and interfere with normal trafficking of mRNAs to distal segments of neurites and with local translation, thereby causing degeneration. In the lab we use a wide range of techniques spanning the fields of Biochemistry, Cell Biology and model organism genetics in Drosophila.